HOE 140 |
| Catalog No.GC15587 |
HOE 140(HOE-140)은 IC50 및 Ki가 각각 1.07nM 및 0.798nM인 브래디키닌 B2 수용체의 강력하고 특이적인 펩티드 길항제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 130308-48-4
Sample solution is provided at 25 µL, 10mM.
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Icatibant (HOE-140) is a selective and specific antagonist of bradykinin B2 receptor with IC50 and Ki of 1.07 nM and 0.798 nM respectively.
References:
[1]. Hock FJ, et al. Hoe 140 a new potent and long acting bradykinin-antagonist: in vitro studies. Br J Pharmacol. 1991 Mar;102(3):769-73.
[2]. George J, et al. Locally Mediated Analgesic Effect of Bradykinin Type 2 Receptor Antagonist HOE 140 During Acute Inflammatory Pain in Rats. J Burn Care Res. 2014 Jan 21.
[3]. Ferreira AP, et al. HOE-140, an antagonist of B2 receptor, protects against memory deficits and brain damage induced by moderate lateral fluid percussion injury in mice. Psychopharmacology (Berl). 2014 May;231(9):1935-48.
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