HS79 |
Catalog No.GC33374 |
HS-79는 선택적 지방산 합성 효소(FASN) 억제제인 Fasnall의 거울상 이성질체입니다. HS-79는 1.57 μM의 IC50으로 삼중수소화 아세테이트가 지질로 통합되는 것을 억제할 수 있습니다.
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Cas No.: 2138838-56-7
Sample solution is provided at 25 µL, 10mM.
HS-79 is an enantiomer of Fasnall, which is a selective fatty acid synthase (FASN) inhibitor. HS-79 is able to inhibit the incorporation of tritiated acetate into lipids with an IC50 of 1.57 μM.
Fasnall, a thiophenopyrimidine selectively targeting FASN through its co-factor binding sites. Fasnall has anti-proliferative activity and induces apoptosis in breast cancer cells[1].
[1]. Alwarawrah Y, et al. Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2(+) Breast Cancer. Cell Chem Biol. 2016 Jun 23;23(6):678-88.
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