Hydrochlorothiazide (Synonyms: HCTZ, NSC 53477, SU 5879) |
| Catalog No.GC17523 |
thiazide 계열의 경구 활성 이뇨제인 Hydrochlorothiazide(HCTZ)는 TGF-β/Smad 신호 전달 경로의 변형을 억제합니다.
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Cas No.: 58-93-5
Sample solution is provided at 25 µL, 10mM.
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Hydrochlorothiazide is a diuretic drug of the thiazide class. Target: OthersHydrochlorothiazide belongs to thiazide class of diuretics. It reduces blood volume by acting on the kidneys to reduce sodium (Na) reabsorption in the distal convoluted tubule. The major site of action in the nephron appears on an electroneutral Na+-Cl co-transporter by competing for the chloride site on the transporter. By impairing Na transport in the distal convoluted tubule, hydrochlorothiazide induces a natriuresis and concomitant water loss. Thiazides increase the reabsorption of calcium in this segment in a manner unrelated to sodium transport. Additionally, by other mechanisms, Hydrochlorothiazide is believed to lower peripheral vascular resistance [1].
References:
[1]. Duarte, J.D. and R.M. Cooper-DeHoff, Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretics. Expert Rev Cardiovasc Ther, 2010. 8(6): p. 793-802.
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