Ibafloxacine (R835) |
| Catalog No.GC33988 |
Ibafloxacine(R835)(R835)은 동물용으로 독점적으로 개발된 fluoroquinolone 항생제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 91618-36-9
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Ibafloxacine (R835) is a fluoroquinolone antibiotic agent that is developed exclusively for veterinary use.
The pharmacokinetic behavior of Ibafloxacin is studied after intravenous administration of a single dose of 15 mg/kg to 6 healthy lactating goats. Plasma concentrations of Ibafloxacin are determined by high-performance liquid chromatography with fluorescence detection. After IV injection Ibafloxacin shows very rapid initial distribution, with a mean half-life of 0.35 h, follows by slower elimination, with a mean half-life of 3.76 h. The elimination half-life of Ibafloxacin after oral administration has been reported to be 3.83 h in dogs and 3.00 h in cats[1].
[1]. Marín P, et al. Pharmacokinetics and milk penetration of ibafloxacin after intravenous administration to lactating goats. Can J Vet Res. 2007 Jan;71(1):74-6.
Animal experiment: | Goats[1]Six Murciano-Granadina female goats 52 to 58 kg in body weight (BW) and 3 to 4 y of age are used. A 5% aqueous solution of Ibafloxacin is prepared from the pure substance and sterilized. The solution is administered by the IV route as a single dose of 15 mg/kg BW. Blood samples (4 mL) are collected from the contralateral jugular vein into heparinized tubes at 0, 5, 10, 15, 30, and 45 min and at 1, 1.5, 2, 4, 6, 8, 10, 12, 24, 32, 48, and 72 h after drug administration. The samples are centrifuged at 1500× g for 15 min, and then the plasma is removed and stored at -45°C until assayed. Milk samples are collected before and at 1, 2, 4, 6, 12, 24, 32, 48, and 72 h after complete evacuation of the udder at each collection period. The concentration of Ibafloxacin is measured in plasma and milk by a modified high-performance liquid chromatography (HPLC) method. |
References: [1]. Marín P, et al. Pharmacokinetics and milk penetration of ibafloxacin after intravenous administration to lactating goats. Can J Vet Res. 2007 Jan;71(1):74-6. | |
| Cas No. | 91618-36-9 | SDF | |
| Canonical SMILES | O=C(C1=CN2C(C)CCC3=C2C(C1=O)=CC(F)=C3C)O | ||
| Formula | C15H14FNO3 | M.Wt | 275.27 |
| Solubility | Soluble in DMSO | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.6328 mL | 18.164 mL | 36.328 mL |
| 5 mM | 0.7266 mL | 3.6328 mL | 7.2656 mL |
| 10 mM | 0.3633 mL | 1.8164 mL | 3.6328 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *