IMB-808 |
| Catalog No.GC70540 |
IMB-808 는 강력한 LXR 알파/베타 이중 흥분제로서 LXR 베타와 LXR 알파에 대한 EC50 값은 각각 0.53 μM과 0.15 μM(GAL4-pGL4-luc을 사용하여 입자는 0.15 μM으로 보고됨).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 870768-70-0
Sample solution is provided at 25 µL, 10mM.
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IMB-808 (0.001 μM-30 μM) significantly dose-dependently induces LXRβ activation under the concentrations ranged from 0.001 μM to 30 μM, with an EC50 of 0.53 μM. In a luciferase reporter assay IMB-808 using GAL4-pGL4-luc reporter plasmid, IMB-808 also could dose-dependently active LXRα with a lower EC50 of 0.15 μM[1].
IMB-808 (0 μM-10 μM; 18 hours) significantly increases protein and mRNA levels of ABCG1 as well as ABCA1 in RAW264.7 macrophages[1].
IMB-808 (0.1 μM, 0.3 μM, 1 μM, 3 μM, or 10 μM; 24 hours) promotes cholesterol efflux towards ApoA-I and HDL dose-dependently and reduces the cellular cholesterol concentration in these two cell lines[1].
References:
[1]. Duo Lu, et al. Identification of a Novel Liver X Receptor Agonist that Regulates the Expression of Key Cholesterol Homeostasis Genes with Distinct Pharmacological Characteristics. Mol Pharmacol. 2017 Apr;91(4):264-276.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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