JAK-IN-24 |
| Catalog No.GC71213 |
JAK-IN-24 는 4μM 또는 1mM ATP의 존재하에 IC50이 각각 0.534와 24nM인 JAK 억제제입니다.
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Cas No.: 2042629-43-4
Sample solution is provided at 25 µL, 10mM.
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JAK-IN-24 (Example 129 ) inhibits JAK with IC50 values of 0.534 and 24 nM at the presence of 4 μM or 1mM ATP respectively[1].
JAK-IN-24 shows stability in human whole blood with t1/2 of 267.223 min[1].
JAK-IN-24 inhibits PBMC IL-15 induced STAT5 phosphorylation with an IC50 of 86.171 nM[1].
References:
[1]. Atli Thorarensen, et al. Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl, pyrrolo[2,3-b]pyridinyl acrylamides and epoxides thereof. Patent. WO2016178110.
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