JW 642 |
| Catalog No.GC17304 |
monoacylglycerol lipase (MAGL) inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1416133-89-5
Sample solution is provided at 25 µL, 10mM.
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JW 642 is a potent inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively.IC50 value: 7.6/14/3.7 nM(mouse/rat/human MAGL) [1]Target: MAGL inhibitorJW 642 is selective for MAGL, requiring much higher concentrations to effectively inhibit fatty acid amide hydrolase activity (IC50s = 31, 14, and 20.6 μM for mouse, rat, and human brain membranes, respectively).
References:
[1]. Chang JW, et al. Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chem Biol. 2012 May 25;19(5):579-88.
Average Rating: 5 (Based on Reviews and 10 reference(s) in Google Scholar.)
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