JZP-430 |
| Catalog No.GC34640 |
JZP-430은 44nM의 IC50을 갖는 α/β-하이드롤라제 도메인 6(ABHD6)의 강력하고 고도로 선택적이고 비가역적인 억제제이며, 지방산 아미드 가수분해효소(FAAH) 및 리소좀산 리파제(LAL)에 비해 ~230배 선택성을 나타냅니다. ).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1672691-74-5
Sample solution is provided at 25 µL, 10mM.
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JZP-430 is a potent, highly selective, irreversible inhibitor of α/β-hydrolase domain 6 (ABHD6) with an IC50 of 44 nM, exhibits ~230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL)[1]. IC50: 44 nM (ABHD6, human)[1]
[1]. Patel JZ, et al. Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors. ChemMedChem. 2015 Feb;10(2):253-65.
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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