Kallidin (380-389) (human, porcine, bovine) (trifluoroacetate salt) (Synonyms: KRPPGFSPFR, Lys-BK, Lysine Bradykinin)

Kallidin (380-389) is a short-lived kinin peptide involved in inflammation and pain.¹ It binds to bradykinin B₂ (IC₅₀ = 0.63 nM) and B₁ receptors (K_i = 3.23 nM) and acts as an agonist.^1,2,3 It is formed in tissue, including the brain, via cleavage of low molecular weight kininogen (LMWK) by kallikrein serine proteases released in response to injury or inflammation and can be converted into bradykinin.¹ Kallidin levels in interstitial muscle are increased in women with work-related trapezius myalgia.⁴

1.Dray, A.Kinins and their receptors in hyperalgesiaCan. J. Physiol. Pharmacol.75(6)704-712(1997) 2.Bastian, S., Loillier, B., Paquet, J.L., et al.Stable expression of human kinin B1 receptor in 293 cells: Pharmacological and functional characterizationBr. J. Pharmacol.122(2)393-399(1997) 3.Hess, J.F., Borkowski, J.A., Macneil, T., et al.Differential pharmacology of cloned human and mouse B2 bradykinin receptorsMol. Pharmacol.45(1)1-8(1994) 4.Gerdle, B., Hilgenfeldt, U., Larsson, B., et al.Bradykinin and kallidin levels in the trapezius muscle in patients with work-related trapezius myalgia, in patients with whiplash associated pain, and in healthy controls - a microdialysis study of womenPain139(3)578-587(2008)