KCC 07 |
| Catalog No.GC50520 |
KCC 07은 강력하고 선택적인 뇌 침투성 MBD2(methyl-CpG-binding domain protein 2) 억제제입니다. KCC 07은 메틸화된 DNA에 대한 MBD2의 결합을 방지하고 항증식성 BAI1/p53/p21 신호전달을 유도하는 뇌 특이적 혈관신생 억제제 1(BAI1)을 활성화합니다. 항암 활성.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 315702-75-1
Sample solution is provided at 25 µL, 10mM.
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MBD2 (Methyl-CpG-binding domain protein 2) inhibitor. Prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1)/p53 signaling. Inhibits medulloblastoma (MB) cell growth in vitro and reduces tumor size in mice bearing MB xenografts. Brain penetrant.
Zhu et al (2018) BAI1 suppresses medulloblastoma formation by protecting p53 from Mdm2-mediated degradation. Cancer Cell 33 1004 PMID:29894688
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)
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