L-902,688 |
| Catalog No.GC44023 |
L-902,688은 Ki가 0.38 nM이고 EC50이 0.6 nM인 강력하고 선택적이며 경구 활성인 EP4 수용체 작용제입니다.
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Cas No.: 634193-54-7
Sample solution is provided at 25 µL, 10mM.
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Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. L-902,688 is a highly potent agonist of the human PGE2 receptor, EP4. It demonstrates a Ki value of 0.38 nM and an EC50 value of 0.6 nM and is >4,000-fold selective for EP4 over other EP and prostanoid receptors. L-902,688 induces thermal hyperalgesia when injected into guinea pig forepaw and increases vasodilation of human pulmonary vein.
Average Rating: 5 (Based on Reviews and 32 reference(s) in Google Scholar.)
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