L-Glutamic γ-monohydroxamate |
| Catalog No.GC67559 |
L-Glutamic γ-monohydroxamate는 항종양제이며 세포 증식을 억제합니다. 821d96072c2d58d8970e76f526b0f6b8L-Glutamic γ-모노하이드록사메이트는 L-히스티딘이 미세혈관 내피 세포로 흡수되는 것을 선택적으로 억제합니다. 821d96072c2d58d8970e76f526b0f6b8L-Glutamic γ-monohydroxamate는 바나듐 리간드로서 포도당 흡수 및 대사를 활성화하여 생체 내 혈당 수준을 감소시킵니다.821d96072c2d58d8970e76f526b0f6b8
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1955-67-5
Sample solution is provided at 25 µL, 10mM.
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L-Glutamic γ-monohydroxamate is an antitumor agent, inhibits cell proliferation. L-Glutamic γ-monohydroxamate selectively inhibits the uptake of L-histidine into microvascular endothelial cell. L-Glutamic γ-monohydroxamate, as a vanadium ligand, activates glucose uptake and metabolism, thus decreases the blood glucose levels in vivo[1][2][3].
[1]. Vila J, et al. In vitro and in vivo anti-tumor activity of L-glutamic acid gamma-monohydroxamate against L1210 leukemia and B16 melanoma. Int J Cancer. 1990 Apr 15;45(4):737-43.
[2]. Sakurai E, et al. Stereoselective transport of histidine in rat lung microvascular endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2002 Jun;282(6):L1192-7.
[3]. Goldwaser I, et al. L-Glutamic acid gamma-monohydroxamate. A potentiator of vanadium-evoked glucose metabolism in vitro and in vivo. J Biol Chem. 1999 Sep 10;274(37):26617-24.
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