l-Naproxen |
Catalog No.GC65492 |
l-나프록센((R)-나프록센)은 (S)-나프록센의 거울상 이성질체입니다. l-나프록센은 Cdc42 및 Rac1(각각 EC50=96μM 및 212μM)을 억제하고 항종양 활성을 나타낼 수 있습니다. l-나프록센은 비스테로이드성 항염증제(NSAID)입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 23979-41-1
Sample solution is provided at 25 µL, 10mM.
l-Naproxen ((R)-Naproxen) is an enantiomer of (S)-Naproxen. l-Naproxen can inhibit Cdc42 and Rac1 (EC50=96 μM and 212 μM, respectively), and show anti-tumor activity[1][2][3].
l-Naproxen (30-1000 μM; 2 h) inhibits Rac1 and Cdc42 activity selectively in cells[3].l-Naproxen (0-300 μM; 48 h) inhibits migration of immortalized human ovarian cancer cells[3].l-Naproxen (300 μM; 48 h) shows activity via a COX-independent mechanism[3].
[1]. Sonika Batra, et al. Enantiomeric Resolution of (RS)-Naproxen and Application of (S)- Naproxen in the Direct and Indirect Enantioseparation of Racemic Compounds by Liquid Chromatography: A Review. Curr Med Chem. 2017;24(8):758-780.
[2]. M Iwaki, et al. Stereoselective disposition of naproxen glucuronide in the rat. Drug Metab Dispos. 1995 Oct;23(10):1099-103.
[3]. Tudor I Oprea, et al. Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases. PLoS One. 2015 Nov 11;10(11):e0142182.
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