Latanoprost-d4 (Synonyms: 17phenyl13,14dihydro trinor Prostaglandin F2αd4 isopropyl ester)

Latanoprost-d₄ contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of latanoprost by GC- or LC-mass spectrometry. Latanoprost is the isopropyl ester of 17-phenyl-13,14-dihydro prostaglandin F_2α. It is a prodrug form of the free acid, which is a potent agonist of the FP receptor in the eye. Latanoprost reduces intraocular pressure in glaucoma patients with few side effects.^1,2,3 The EC₅₀ value of latanoprost for (free acid) for FP receptors is 3.6 nM.⁴

1.LindÉn, C., Nuija, E., and Alm, A.Effects on IOP restoration and blood-aqueous barrier after long term treatment with latanoprost in open angle glaucoma and ocular hypertensionBritish Journal of Ophthalmology81370-372(1997) 2.Camras, C.B., Alm, A., Watson, P., et al.Latanoprost, a prostaglandin analog, for glaucoma therapy. Efficacy and safety after 1 year of treatment in 198 patientsOphthalmology1031916-1924(1996) 3.Alm, A., Villumsen, J., TÖrnquist, P., et al.Intraocular pressure-reducing effect of PhXA41 in patients with increased eye pressure. A one-month studyOphthalmology1001312-1317(1993) 4.Stjernschantz, J., and Resul, B.Phenyl substituted prostaglandin analogs for glaucoma treatmentDrugs of the Future17691-704(1992)