Lecimibide |
| Catalog No.GC71495 |
Lecimibide (Dup 128) 는 고지혈증 연구에 사용되는 강력하고 특이한 아세틸 보조효소 a: 콜레스테롤 아세틸 전이효소(ACAT) 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 130804-35-2
Sample solution is provided at 25 µL, 10mM.
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Lecimibide (DuP 128)(10 μM, 24 h) can inhibit 85% of the cellular esterification reaction in HepG2 cells[1].
Lecimibide (DuP 128) (i.v., 2.2 mg/kg/day) significantly reduces total plasma triglyceride and very low-density lipoprotein (VLDL) triglyceride concentrations in pigs fed high fat and cholesterol levels, respectively 36% and 31%. There are no significant effects on total cholesterol, VLDL cholesterol, LDL cholesterol, HDL cholesterol, or LDL apoB concentrations[2].
References:
[1]. L J Wilcox, et al. Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP. J Lipid Res. 2001 May;42(5):725-34.
[2]. J R Burnett, et al. Inhibition of cholesterol esterification by DuP 128 decreases hepatic apolipoprotein B secretion in vivo: effect of dietary fat and cholesterol. Biochim Biophys Acta. 1998 Jul 31;1393(1):63-79.
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