Lenalidomide-5-aminomethyl hydrochloride |
Catalog No.GC63806 |
레날리도마이드-5-아미노메틸 염산염은 CRBN 단백질 모집에 사용되는 레날리도마이드 기반 세레블론(CRBN) 리간드입니다. 레날리도마이드-5-아미노메틸 염산염은 링커에 의해 단백질 리간드에 연결되어 PROTAC을 형성할 수 있습니다.
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Cas No.: 1158264-69-7
Sample solution is provided at 25 µL, 10mM.
Lenalidomide-5-aminomethyl hydrochloride is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-aminomethyl hydrochloride can be connected to the ligand for protein by a linker to form PROTAC[1]
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
[1]. Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25.
[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.
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