Lenalidomide-C5-amido-Boc |
| Catalog No.GC63474 |
레날리도마이드-C5-아미도-Boc는 CRBN 단백질 모집에 사용되는 레날리도마이드 기반 세레블론 리간드입니다. 레날리도마이드-C5-아미도-Boc는 링커에 의해 단백질에 대한 리간드에 연결되어 PROTAC을 형성할 수 있습니다.
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Cas No.: 2138441-25-3
Sample solution is provided at 25 µL, 10mM.
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Lenalidomide-C5-amido-Boc is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-amido-Boc can be connected to the ligand for protein by a linker to form PROTAC[1].
[1]. Wang, Shaomeng, et al. Preparation of phthalimide-based compounds as monofunctional intermediates for ligand-dependent target protein degradation. World Intellectual Property Organization, WO2017176958 A1 2017-10-12.
[2]. Robbins, Daniel, et al. WBifunctional compounds for degrading BTK via ubiquitin proteasome pathway. World Intellectual Property Organization, WO2021091575 A1 2021-05-14.
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