Leniolisib phosphate |
| Catalog No.GC71524 |
Leniolisib phosphate 는 효과적이고 선택적인 PI3K 델타 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1354691-97-6
Sample solution is provided at 25 µL, 10mM.
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Expression of APDS mutant p110δ in cell lines and patient-derived lymphocytes lead to increased pathway activity, measured as phosphorylation of AKT or S6, which is suppressed by Leniolisib phosphate in a concentration dependent way[1].
References:
[1]. Rao V, et al. Effective 'Activated PI3Kd Syndrome' -targeted therapy with PI3Kd inhibitor leniolisib. The New England journal of medicine: NEJM. ISSN 0028-4793; 1533-4406
[2]. Hoegenauer K, et al. Discovery of CDZ173 (Leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors. ACS Med Chem Lett. 2017 Aug 25;8(9):975-980.
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