[Leu144, Arg147]-PLP (139-151) (trifluoroacetate salt) |
| Catalog No.GC90541 |
PLP 펩타이드의 돌연변이 단편
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![[Leu144, Arg147]-PLP (139-151) (trifluoroacetate salt) Chemical Structure](/media/struct/GC9/GC90541.png "[Leu144, Arg147]-PLP (139-151) (trifluoroacetate salt) Chemical Structure")
Sample solution is provided at 25 µL, 10mM.
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[Leu144,Arg147]-PLP (139-151) is a mutant peptide fragment of myelin proteolipid protein (PLP) containing tryptophan-to-leucine and histidine-to-arginine substitutions at positions 144 and 147, respectively.1 Immunization with [Leu144, Arg147]-PLP (139-151) (50 µg) emulsified in complete Freund’s adjuvant (CFA) increases spleen levels of IL-4 in mice. It inhibits Th1 cell activation in vitro but not in vivo, where it induces the generation of regulatory T cells.2 Preimmunization with [Leu144, Arg147]-PLP (139-151) delays the onset of experimental autoimmune encephalomyelitis (EAE) induced by the encephalitogenic peptides PLP (178-191), myelin oligodendrocyte protein (MOG) (92-106), or myelin basic protein (MBP) in mice.
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