Linoleoyl Glycine (Synonyms: Glycine Linoleamide, LinGly, NLinoleoyl Glycine) |
| Catalog No.GC44074 |
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Cas No.: 2764/3/6
Sample solution is provided at 25 µL, 10mM.
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Arachidonyl glycine, the conjugate of arachidonic acid and glycine produced in mammalian brain, skin, and spinal cord, is a structural analog of anandamide (AEA) that is reported to have analgesic activities in whole animal experiments. It has poor affinity for the central cannabinoid (CB1) receptor, high-affinity for the G protein-coupled receptor GPR-18, and is metabolically regulated by fatty acid amide hydrolase (FAAH) activity. LinGly is an endogenous homolog of linoleoyl ethanolamide, an arachidonyl glycine. It inhibits the hydrolysis of AEA in FAAH-containing N18TG2 cell membranes with an IC50 value of ~25 µM, which is less potent than that of arachidonyl glycine (IC50 = 7 µM). The biological significance of LinGly has not yet been determined.
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