Lipid 88 |
| Catalog No.GC91631 |
Lipid 88 is an ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2982842-99-7
Sample solution is provided at 25 µL, 10mM.
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Lipid 88 is an ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.[1] LNPs containing lipid 88 and encapsulating mRNA encoding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein increase anti-spike glycoprotein IgG titers in bronchoalveolar lavage fluid (BALF), as well as increase the percentage of CD8+, CD8+CD44+, CD4+, and CD4+CD44+ T cells in the lungs and spleen, in mice after two doses three weeks apart. LNPs containing lipid 88 and encapsulating mRNA encoding SARS-CoV-2 spike glycoprotein inhibit reductions in body weight, increase serum levels of anti-spike glycoprotein IgG and IgA titers, and reduce lung and nasal wash viral titers in a hamster model of SARS-CoV-2 Omicron BQ.1 subvariant infection.
References:
[1].Ye, Z., Bonam, S.R., McKay, L.G.A., et al.Monovalent SARS-COV-2 mRNA vaccine using optimal UTRs and LNPs is highly immunogenic and broadly protective against Omicron variantsProc. Natl. Acad. Sci. USA120(52)e2311752120(2023).
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