Lipopolysaccharides (Synonyms: LPS) |
| Catalog No.GC65924 |
Lipopolysaccharides(LPS)는 그람 음성 박테리아의 외막의 외엽에서 파생된 내독소입니다. 821d96072c2d58d8970e76f526b0f6b8리포폴리사카라이드는 항원 O-특이적 사슬, 코어 올리고당 및 지질 A로 구성됩니다. 리포폴리사카라이드는 면역 체계를 활성화하는 병원성 관련 분자 패턴(PAMP)입니다. 821d96072c2d58d8970e76f526b0f6b8Lipopolysaccharides는 면역 세포에서 TLR-4를 활성화합니다. 821d96072c2d58d8970e76f526b0f6b8이 제품은 대장균 O55:B5에서 파생됩니다.821d96072c2d58d8970e76f526b0f6b8
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Sample solution is provided at 25 µL, 10mM.
Lipopolysaccharides (LPS) is an endotoxin derived from the outer leaflet of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consists of an antigen O-specific chain, a core oligosaccharide and lipid A. Lipopolysaccharides is a pathogenic associated molecular pattern (PAMP) that activates the immune system. Lipopolysaccharides activates TLR-4 on immune cells[1][2][3]. This product is derived from Escherichia coli O55:B5.
Lipopolysaccharides (10-80 μg/mL) selectively decreases THir (tyrosine hydroxylase immunoreactive) cells and increases culture media levels of interleukin1β (IL-1β) and tumor necrosis factor-α (TNF-α) as well as nitrite (an index of nitric oxide (NO) production)[4].
Lipopolysaccharides (1.5 mg/kg; i.p.; once) induces sickness and hypothermia in mice, and induces a greater and more prolonged sickness response in adult male mice[3].
| Animal Model: | Female and male CD1 mice[3] |
| Dosage: | 1.5mg/kg |
| Administration: | Intraperitoneal injection, once |
| Result: | Induced sickness behavior in all mice, but adult mice displayed more sickness than pubertal mice and adult males remained sick for a longer period of time than adult females. Caused a decrease in body temperature for all mice, but this decrease was greatest in adult males. Increased pro- and anti-inflammatory cytokines at various levels in pubertal and adult male and female mice, resulted in age and sex differences in cytokine concentrations following immune challenge. Only adult males and females treated with LPS displayed significantly more IL-6 than their saline controls, and pubertal males and females and adult females displayed significantly more IL-10 than their saline controls. All the mice displayed significantly more IL-12 and TNF-α than their saline controls. |
| Cas No. | SDF | ||
| Synonyms | LPS | ||
| Formula | M.Wt | ||
| Solubility | H2O : 5 mg/mL (Need ultrasonic) | Storage | Store at -20°C,protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
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