Lometrexol hydrate (Synonyms: DDATHF, (6R)-Dideazatetrahydrofolate) |
| Catalog No.GC39820 |
항퓨린 항엽산제인 로메트렉솔(DDATHF) 수화물은 글리신아미드 리보뉴클레오티드 포르밀트랜스퍼라제(GARFT)의 활성을 억제할 수 있지만 검출 가능한 수준의 DNA 가닥 파손을 유도하지 않습니다. 로메트렉솔 수화물은 새로운 퓨린 합성을 추가로 억제하여 비정상적인 세포 증식 및 세포자멸사, 심지어 세포 주기 정지를 유발할 수 있습니다. 로메트렉솔 수화물은 항암 활성이 있습니다. 로메트렉솔 수화물은 또한 강력한 인간 세린 하이드록시메틸트랜스퍼라제1/2(hSHMT1/2) 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1435784-14-7
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Lometrexol hydrate (DDATHF hydrate), an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol hydrate can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol hydrate has anticancer activity[1][2].
[1]. Xu L, et al. The effect of inhibiting glycinamide ribonucleotide formyl transferase on the development of neural tube in mice. Nutr Metab (Lond). 2016 Aug 23;13(1):56. [2]. Julie L Bronder, et al. Antifolates Targeting Purine Synthesis Allow Entry of Tumor Cells Into S Phase Regardless of p53 Function. Cancer Res. 2002 Sep 15;62(18):5236-41.
Average Rating: 5 (Based on Reviews and 20 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *