LXW7 TFA |
| Catalog No.GC39593 |
Arg-Gly-Asp(RGD)를 포함하는 고리형 펩티드인 LXW7 TFA는 인테그린 αvβ3 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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LXW7 TFA, a cyclic peptide containing Arg-Gly-Asp (RGD), has a high binding affinity to αvβ3 integrin with an IC50 of 0.68 μM[1]. LXW7 increases phosphorylation of VEGFR-2 and activation of ERK1/2[2]. Anti-inflammatory effect[3].
[1]. Xiao W, et al. The use of one-bead one-compound combinatorial library technology to discover high-affinity αvβ3 integrin and cancer targeting arginine-glycine-aspartic acid ligands with a built-in handle. Mol Cancer Ther. 2010 Oct;9(10):2714-23. [2]. Hao D, et al. Discovery and Characterization of a Potent and Specific Peptide Ligand Targeting Endothelial Progenitor Cells and Endothelial Cells for Tissue Regeneration. ACS Chem Biol. 2017 Apr 21;12(4):1075-1086. [3]. Fang T, et al. LXW7 ameliorates focal cerebral ischemia injury and attenuates inflammatory responses in activated microglia in rats. Braz J Med Biol Res. 2016 Aug 1;49(9):e5287.
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)
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