LY2365109 (hydrochloride) |
| Catalog No.GC90597 |
GlyT1a 억제제
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1779796-27-8
Sample solution is provided at 25 µL, 10mM.
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LY2365109 is an inhibitor of glycine transporter 1a (GlyT1a; IC50 = 15.8 nM in BE2-C cells expressing the human transporter).1 It is selective for GlyT1a over GlyT2 (IC50 = >30 µM in RD cells expressing the human transporter). LY2365109 (10 mg/kg) induces locomotor peractivity, impaired gait, compulsive walking, and labored breathing, as well as impairs the ability to stand, in rats.1 It also prevents maximal electroshock-induced acute seizures in mice and decreases the number of seizures in an electroshock-induced rat model of chronic epilepsy when administered at doses of 30 and 10 mg/kg, respectively.2
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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