M 30 dihydrochloride |
Catalog No.GC50329 |
M 30 dihydrochloride는 경구 활성, 뇌 투과성 및 뇌 선택적 비가역적 MAO-A(IC50=37nM) 및 MAO-B(IC50=57nM) 억제제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 64821-19-8
Sample solution is provided at 25 µL, 10mM.
Potent and brain selective monoamine oxidase (MAO) inhibitor (EC50 values are 37 and 57 nM for MAO-A and MAO-B, respectively). Also an iron chelator with antioxidant properties. Protects cells against 6-OHDA induced apoptosis. Attenuates MPTP depletion of DA and increases striatal monoamine levels in a mouse Parkinson's disease model.
Zheng et al (2005) Novel potential neuroprotective agents with both iron chelating and amino acid-based derivatives targeting central nervous system neurons. Biochem.Pharmacol. 70 1642 PMID:16226724 |Zheng (2005) Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases: in vitro studies on antioxidant activity, prevention of lipid peroxide formation and monoamine oxidase inhibition. J.Neurochem. 95 68 PMID:16181413 |Gal et al (2005) Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases. In vivo selective brain monoamine oxidase inhibition and prevention of MPTP-induced striatal DA depletion. J.Neurochem. 95 79 PMID:16181414
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