m-PEG5-succinimidyl carbonate |
Catalog No.GC67138 |
m-PEG5-석신이미딜 카보네이트는 항체-약물 접합체(ADC)의 합성에 사용되는 절단 불가능한 5단위 PEG ADC 링커입니다. 821d96072c2d58d8970e76f526b0f6b8m-PEG5-석신이미딜 카보네이트는 PROTAC의 합성에 사용될 수 있는 PEG/알킬/에테르 기반 PROTAC 링커입니다.821d96072c2d58d8970e76f526b0f6b8
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Cas No.: 1058691-00-1
Sample solution is provided at 25 µL, 10mM.
m-PEG5-succinimidyl carbonate is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG5-succinimidyl carbonate is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
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