Maleimido-tri(ethylene glycol)-propionic acid |
| Catalog No.GC60236 |
말레이미도-트리(에틸렌 글리콜)-프로피온산은 항체-약물 접합체(ADC) 합성에 사용되는 절단 가능한 ADC 링커입니다. 말레이미도-트리(에틸렌 글리콜)-프로피온산은 부위 특이적 시스테인 돌연변이 트라스투주맙-A114C 접합을 위한 네오림포스틴 기반 ADC 전구체의 제조에 사용됩니다. 말레이미도-트리(에틸렌 글리콜)-프로피온산은 또한 PROTAC 합성에 사용할 수 있는 PEG 기반 PROTAC 링커로 사용할 수 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 518044-40-1
Sample solution is provided at 25 µL, 10mM.
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Maleimido-tri(ethylene glycol)-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Maleimido-tri(ethylene glycol)-propionic acid is used for the preparation of neolymphostin-based ADC precursors for site-specific cysteine mutant trastuzumab-A114C conjugation[1].
Mal-PEG3-C2-acid can be used to synthesis linker-payload 16 (compound 15) and 20 (compound 18). linker-payload 16 amd 20 is conjugated to DAR1.9 and DAR1.7[1].ADC 23 and 24 are Neolymphostin ADCs that composes of DAG 1.9 and DAG1.7 linked to PIKK inhibitors with linker-payload 16 and 20, respectively[1].ADC24 demonstrates cytotoxic activity against BT474 and N87 cell lines with IC50 of 195 and 202 nM, respectively[1].ADC23 demonstrates cytotoxic activity against BT474 and N87 cell lines with IC50 of 286 and 274 nM, respectively[1].
[1]. Zhou D,et al. Novel PIKK inhibitor antibody-drug conjugates: Synthesis and anti-tumor activity.Bioorg Med Chem Lett. 2019 Apr 1;29(7):943-947.
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