MC-VA-PABC-MMAE |
| Catalog No.GC65109 |
MC-VA-PABC-MMAE는 ADC에 대한 약물-링커 접합체입니다. MC-VA-PABC-MMAE에는 ADC 링커(펩티드 MC-VA-PABC)와 강력한 튜불린 중합 억제제 MMAE가 포함되어 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1818864-51-5
Sample solution is provided at 25 µL, 10mM.
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MC-VA-PABC-MMAE is a drug-linker conjugate for ADC. MC-VA-PABC-MMAE contains the ADCs linker (peptide MC-VA-PABC) and a potent tubulin polymerization inhibitor MMAE [1][2].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
[1]. Wang Y, et al. Development of applicable thiol-linked antibody-drug conjugates with improved stability and therapeutic index. Drug Deliv. 2022 Dec;29(1):754-766. [2]. Cazzamalli S, et al. Linker stability influences the anti-tumor activity of acetazolamide-drug conjugates for the therapy of renal cell carcinoma. J Control Release. 2017 Jan 28;246:39-45.
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