Mertansine (Synonyms: DM1 Compound) |
| Catalog No.GC19244 |
Mertansine (DM1)은 마이크로튜뷰린 억제제로, 마이크로튜뷰링의 끝단에 결합하여 마이크로튜뷰링의 동적성을 억제합니다.
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Cas No.: 139504-50-0
Sample solution is provided at 25 µL, 10mM.
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Mertansine (DM1) is a microtubulin inhibitor which binds at the tips of microtubules and suppresses the dynamicity of microtubules.. Mertansine is an antibody-conjugatable maytansinoid that was developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery.
References:
[1]. Manu Lopus et al. Maytansine and Cellular Metabolites of Antibody-Maytansinoid Conjugates Strongly Suppress Microtubule Dynamics by Binding to Microtubules.
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