Microcystin-LA (Synonyms: CyanoginosinLA, Toxin BE4 (M. aeruginosa)) |
Catalog No.GC18859 |
천연 독소인 마이크로시스틴 LA는 각각 0.3 및 0.3 nM의 IC50으로 세린-트레오닌 단백질 포스파타제 PP1 및 PP2A를 억제함으로써 세포독성 효과를 발휘합니다.
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Cas No.: 96180-79-9
Sample solution is provided at 25 µL, 10mM.
Microcystins are hepatotoxic cyclic heptapeptide toxins produced by cyanobacteria. They are responsible for periodic poisonings of humans and livestock following consumption of freshwater in areas where the blue-green algae are endemic. The toxicity of microcystins is initiated by the inhibition of the catalytic activity of protein phosphatase (PP) 1 and PP2A. Microcystin-LA differs from the major microcystin variant LR with the substitution of alanine in place of the arginine. It inhibits both PP1C and PP2A with an IC50 value of 0.3 nM.
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