ML324 (Synonyms: CID-44143209) |
| Catalog No.GC12557 |
ML324는 항바이러스 활성이 있는 강력한 JMJD2 데메틸라제 억제제입니다. ML324는 또한 4.9μM의 IC50으로 히스톤 데메틸라제 KDM4B에 대한 억제를 나타냅니다. ML324는 바이러스 IE 유전자 발현 억제를 통해 단순 헤르페스 바이러스(HSV) 및 인간 거대 세포 바이러스(hCMV) 감염 모두에 대해 강력한 항바이러스 활성을 가지고 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1222800-79-4
Sample solution is provided at 25 µL, 10mM.
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ML324 is a potent and cell-permeable JMJD2 demethylase inhibitor (IC50 = 920 nM). [1]
Jumonji-domain-containing proteins (JMJD) is the largest class of N ε -methyl lysine demethylase, an enzyme that demethylates the tri-methylated H3K9. JMJD takes part in gene transcription regulation. [1]
ML324 acted as an antiviral agent that effectively inhibited HSV and hCMV IE gene expression in HFF and MRC-5 cells, resulted in suppression of HSV plaques formation and inhibition of HSV infection spread. [1]
ML324 also blocked HSV-1 reactivation and inhibited the formation of HSV plaque in mouse ganglia explant model of latently infected mice. [1]
References:
1.Rai G, Kawamura A, Tumber A, Liang Y, Vogel JL, Arbuckle JH, Rose NR,
Dexheimer TS, Foley TL, King ON, Quinn A, Mott BT, Schofield CJ, Oppermann U,Jadhav A, Simeonov A, Kristie TM, Maloney DJ. Discovery of ML324, a JMJD2
demethylase inhibitor with demonstrated antiviral activity. 2012 Dec 17 [updated 2013 Sep 16]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
Average Rating: 5 (Based on Reviews and 39 reference(s) in Google Scholar.)
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