ML364 |
| Catalog No.GC32720 |
ML364는 항증식 활성이 있는 선택적 유비퀴틴 특이적 펩티다제 2(USP2) 억제제(IC50=1.1μM)로, USP2(Kd=5.2μM)에 직접 결합하여 세포의 사이클린 D1 분해를 증가시키고 세포 주기 정지를 유발합니다. ML364는 미토콘드리아 ROS 수준을 증가시키고 ATP의 세포 내 함량을 감소시킵니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1991986-30-1
Sample solution is provided at 25 µL, 10mM.
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ML364 is an inhibitor of ubiquitin specific peptidase 2 (USP2), and can be used for the research of breast cancer, extracted from patent WO 2016134026 A1, compound Figure 10G.
[1]. Methods and materials for assessing chemotherapy responsiveness and treating cancer. WO 2016134026 A1
Average Rating: 5 (Based on Reviews and 13 reference(s) in Google Scholar.)
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