MrgprX2 antagonist-2 |
| Catalog No.GC70912 |
MrgprX2 antagonist-2는 특허 WO2021092262A1에서 추출된 MrgprX2 길항제로, 실시예 E163.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2642346-30-1
Sample solution is provided at 25 µL, 10mM.
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MRGPRX2, a member of the Mas-related gene family, was found to be expressed in sensory neurons, mast cells and, most recently, in keratinocytes. MRGPRX2 mRNA is present in adipose tissue, esophagus, urinary bladder, lungs with the highest levels found in skin. Activation of MRGPRX2 leads to mast cell degranulation with subsequent pseudo-allergic reactions[2].
References:
[1]. CEVIKBAS F, et, al. Mrgprx2 antagonists and uses thereof. WO2021092262A1.
[2]. Porebski G, et, al. Mas-Related G Protein-Coupled Receptor-X2 (MRGPRX2) in Drug Hypersensitivity Reactions. Front Immunol. 2018 Dec 20;9:3027.
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