MSN-125 |
| Catalog No.GC61096 |
MSN-125는 강력한 Bax 및 Bak 올리고머화 억제제입니다. MSN-125은 IC50이 4 μM인 미토콘드리아 외막 투과성 (MOMP)을 방지합니다. MSN-125은 HCT-116, BMK 세포 및 원시 피질 신경세포에서 Bax / Bak 매개의 세포사 죽음을 강력하게 억제하며, 원시 신경세포를 글루타메이트 독성으로부터 보호합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1592908-16-1
Sample solution is provided at 25 µL, 10mM.
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MSN-125 is a potent Bax and Bak oligomerization inhibitor. MSN-125 prevents mitochondrial outer membrane permeabilization (MOMP) with an IC50 of 4 μM. MSN-125 potently inhibits Bax/Bak-mediated apoptosis in HCT-116, BMK Cells, and primary cortical neurons, protects primary neurons against glutamate excitotoxicity[1].
MSN-125 inhibits tBid/Bax-mediated MOMP in a concentration-dependent manner[1].
[1]. Niu X, et al. A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection. Cell Chem Biol. 2017 Apr 20;24(4):493-506.e5.
Average Rating: 5 (Based on Reviews and 9 reference(s) in Google Scholar.)
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