NAV 26 |
| Catalog No.GC50071 |
NAV 26(화합물 26)은 0.37μM의 IC50을 갖는 선택적 전압 개폐 나트륨 채널 Nav1.7 차단제입니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1198160-14-3
Sample solution is provided at 25 µL, 10mM.
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Selective Nav1.7 channel blocker (IC50 = 370 nM). Exhibits >85-fold selectivity for Nav1.7 over Nav1.5 and hERG channels. Reduces nociceptive behavior in rat models of pain.
Macsari et al (2012) 3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na(V)1.7 with efficacy in rat pain models. J.Med.Chem. 55 6866 PMID:22770500
Average Rating: 5 (Based on Reviews and 20 reference(s) in Google Scholar.)
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