NCI 126224 |
| Catalog No.GC91175 |
TLR4 억제제
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 65974-52-9
Sample solution is provided at 25 µL, 10mM.
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NCI 126224 is a toll-like receptor 4 (TLR4) antagonist.1 NCI 126224 selectively inhibits nitric oxide (NO) production induced by the TLR4 agonist LPS (IC50 = 0.31 µM) over the TLR7/8 agonist R-848 , TLR1/2 agonist Pam3CSK4 , and TLR3 agonist poly(I:C) in RAW 264.7 macrophages but also inhibits NO production induced by the TLR2/6 agonist FSL-1 in the same cells at 0.6 µM. NCI 126224 inhibits LPS-induced NF-κB activity in a reporter assay using BV-2 microglial cells and LPS-induced increases in IL-1β and TNF-α levels in RAW 264.7 macrophages (IC50s = 5.92, 0.42, and 1.54 µM, respectively).
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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