Nicorandil (Synonyms: 2-Nicotinamidoethyl nitrate, SG-75) |
| Catalog No.GC15552 |
Nicorandil(SG-75)은 강력한 칼륨 채널 활성제이며 혈관 뉴클레오시드 이인산 의존성 K+ 채널 및 심장 ATP 민감성 K+ 채널(KATP)을 표적으로 합니다.
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Cas No.: 65141-46-0
Sample solution is provided at 25 µL, 10mM.
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Nicorandil (SG-75) is potassium channel activator.
Nicorandil (SG-75) is a vasodilatory drug used to treat angina. Nicorandil (SG-75) stimulates guanylate cyclase to increase formation of cyclic GMP (cGMP). cGMP activates protein kinase G (PKG) which phosphorylates and inhibits GTPase RhoA and decreases Rho-kinase activity. Reduced Rho-kinase activity permits an increase in myosin phosphatase activity, decreasing the calcium sensitivity of the smooth muscle. PKG also activates the sarcolemma calcium pump to remove activating calcium. PKG acts on K+ channels to promote K+ efflux and the ensuing hyperpolarization inhibits voltage-gated calcium channels. Overall, this leads to relaxation of the smooth muscle and coronary vasodilation[1][2].
References:
[1]. Nakae, I., et al., Effects of intravenous nicorandil on coronary circulation in humans: plasma concentration and action mechanism. J Cardiovasc Pharmacol, 2000. 35(6): p. 919-25.
[2]. Sauzeau, V., et al., Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular smooth muscle. J Biol Chem, 2000. 275(28): p. 21722-9.
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