Nociceptin (1-13)NH2 |
| Catalog No.GC12316 |
노시셉틴(1-13)NH2는 쥐의 정관에 대해 pEC50이 7.9이고 쥐의 전뇌막에 결합하는 경우 Ki가 0.75nM인 강력한 ORL1 수용체(오피오이드 수용체 유사 1 수용체, OP4) 작용제입니다.
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Cas No.: 178064-02-3
Sample solution is provided at 25 µL, 10mM.
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Nociceptin (1-13), amide is a potent ORL1 (OP4) receptor agonist with a pEC50 of 7.9 for mouse vas deferens and a Ki of 0.75 nM for binding to rat forebrain membranes[1][2].
References:
[1]. Varani K, et al. Nociceptin receptor binding in mouse forebrain membranes: thermodynamic characteristics and structure activity relationships. Br J Pharmacol. 1998 Dec;125(7):1485-90.
[2]. Calo' G, et al. Pharmacology of nociceptin and its receptor: a novel therapeutic target. Br J Pharmacol. 2000 Apr;129(7):1261-83.
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