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NPBA

Catalog No.GC70811

NPBA 칼륨 K2P 채널 TASK-3(KCNK9) 흥분제는 직렬구멍 구조역 약내향 정류 K+채널(TWIK2) 차단제의 일종이다.

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NPBA Chemical Structure

Cas No.: 524033-40-7

Size 가격 재고 수량
5 mg
US$86.00
재고 있음
10 mg
US$135.00
재고 있음
25 mg
US$279.00
재고 있음
50 mg
US$446.00
재고 있음
100 mg
US$716.00
재고 있음

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents
NPBA, a potassium K2P channel TASK-3 (KCNK9) agonist, is a tandem pore domain weak inward rectifying K+ channel (TWIK2) channel blocker. NPBA suppresses NLRP3 inflammasome activation in macrophages.

References:
[1]. Fuyun Tian, et al. A Small-Molecule Compound Selectively Activates K2P Channel TASK-3 by Acting at Two Distant Clusters of Residues. Mol Pharmacol. 2019 Jul;96(1):26-35.
[2]. Yuanxing Zhi, et al. A novel TWIK2 channel inhibitor binds at the bottom of the selectivity filter and protects against LPS-induced experimental endotoxemia in vivo. Biochem Pharmacol. 2023 Dec:218:115894.

리뷰

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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