NSC194598 |
| Catalog No.GB40300 |
NSC194598 is a p53 DNA-binding inhibitor with an in vitro IC50 value of 180 nM. NSC194598 selectively inhibited DNA binding by p53 and homologs p63/p73, but did not affect E2F1, TCF1, and c-Myc. Furthermore, NSC194598 suppressed p53 transcriptional output after DNA damage in culture and increased the survival of mice after irradiation.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 5358-76-9
Sample solution is provided at 25 µL, 10mM.
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NSC194598 is a p53 DNA-binding inhibitor with an in vitro IC50 value of 180 nM. NSC194598 selectively inhibited DNA binding by p53 and homologs p63/p73, but did not affect E2F1, TCF1, and c-Myc. Furthermore, NSC194598 suppressed p53 transcriptional output after DNA damage in culture and increased the survival of mice after irradiation.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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