Nur77 modulator 1 |
| Catalog No.GC62416 |
Nur77 변조기 1은 우수한 Nur77 결합제입니다(KD = 3.58μM). Nur77 조절제 1은 Nur77 발현을 상향 조절하고, Nur77의 세포내 국소화를 매개하고, Nur77 의존적 ER 스트레스와 자가포식을 유도하고, 세포 사멸을 초래합니다. 항간종 활성.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2469975-55-9
Sample solution is provided at 25 µL, 10mM.
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Nur77 modulator 1 is a good Nur77 binder (KD = 3.58 μM). Nur77 modulator 1 up-regulates Nur77 expression, mediates sub-cellular localization of Nur77, induces Nur77-dependent ER stress and autophagy, and results in cell apoptosis. Anti-hepatoma activity[1].
Nur77 modulator 1 (10g, 0-20 μM) displays potent and broad-spectrum antiproliferative activity against all tested three hepatoma cell lines (HepG2, QGY-7703, and SMMC-7721), and less cytotoxicity against LO2 cells (human normal liver cell line)[1].Nur77 modulator 1 (10g, ) could specifically up-regulate the expression of Nur77 in a dose-dependent manner[1].Nur77 modulator 1 (10g, 2.0 μM) induces Nur77-dependent apoptosis[1].Nur77 modulator 1 (10g, 2.0 μM) increased LC3-II and Beclin1 protein levels in a dose-dependent manner (10g treatment does not enhance p62 degradation, indicating that autophagy induced by 10g is incomplete)[1].
Nur77 modulator 1 (10g, 10 and 20 mg/kg/day) exhibits significant anti-tumor activity in mouse hepatoma HepG2 xenograft with good tolerability[1].
[1]. Baicun Li, et al. Design, synthesis, and biological evaluation of 5-((8-methoxy-2-methylquinolin-4-yl)amino)-1H-indole-2-carbohydrazide derivatives as novel Nur77 modulators. Eur J Med Chem. 2020 Oct 15;204:112608.
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