NVS-ZP7-4 |
| Catalog No.GC34323 |
NVS-ZP7-4는 아연 수송체 SLC39A7(ZIP7) 억제제로 ER 아연 수준 조절의 영향을 조사하고 Notch 경로에서 새로운 약물 가능 노드로서 ZIP7을 조사하는 최초의 화학적 도구이기도 합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2349367-89-9
Sample solution is provided at 25 µL, 10mM.
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NVS-ZP7-4 is a Zinc transporter SLC39A7 (ZIP7) inhibitor that is also the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel druggable node in the Notch pathway.
NVS-ZP7-4 increases ER zinc levels, suggesting functional modulation of ZIP7[1].
[1]. Nolin E, et al. Discovery of a ZIP7 inhibitor from a Notch pathway screen. Nat Chem Biol. 2019 Feb;15(2):179-188.
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