NXPZ-2 |
Catalog No.GC71072 |
NXPZ-2 는 경구용 활성 Keap1-Nrf2 단백질-단백질 상호작용(PPI) 억제제로, Ki 95nM, EC50 120 및 170nM이다.
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Cas No.: 2254492-08-3
Sample solution is provided at 25 µL, 10mM.
NXPZ-2 (0-200 μM, 7 days) has no obvious toxicity on primary cortical neuron[1].
NXPZ-2 (Male ICR mice, 52.5/105/210 mg/kg, p.o., once daily for 7 days) improves AD mice learning and memorizing function including increased spontaneous alternation, increases number of active avoidance times, shortened escape latency, increased the time spent in the target quadrant and number of platform crossing[1].
NXPZ-2 (Male ICR mice, 52.5/105/210 mg/kg, p.o., once daily for 7 days) rescues the brain structure damage and lowers dead neuron numbers of AD mice with no obvious toxicity on mouse organs[1].
NXPZ-2 (Male ICR mice, 52.5/105/210 mg/kg, p.o., once daily for 7 days) alleviates oxidative stress by increasing Nrf2 expression levels, and promotes Nrf2’s cytoplasm to nuclear translocation, and improves cognitive dysfunction by elevating Nrf2 in both the central nervous system and peripheral blood[1].
References:
[1]. Yi Sun, et al. Direct inhibition of Keap1-Nrf2 Protein-Protein interaction as a potential therapeutic strategy for Alzheimer's disease. Bioorg Chem. 2020 Oct;103:104172.
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