OB 24 hydrochloride |
| Catalog No.GC50348 |
OB 24 염산염은 헴 옥시게나제-1(HO-1)의 강력한 억제제입니다. 열 충격 단백질 계열의 구성원인 헴 옥시게나제-1은 산화 스트레스의 센서 및 조절자로서 핵심적인 역할을 합니다. OB 24 염산염은 시험관 내 세포 증식과 생체 내 종양 성장 및 림프절/폐 전이를 유의하게 억제했습니다. OB 24 염산염은 진행성 전립선암(PCA) 연구에 대한 잠재력이 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 939825-12-4
Sample solution is provided at 25 µL, 10mM.
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Potent and selective heme oxygenase 1 (HO-1) inhibitor (IC50 values are 1.9 and >100 μM for HO-1 and HO-2 respectively), reduces protein carbonylation and reactive oxygen species formation in advanced prostate cancer cells (PCA). Inhibits cell proliferation in vitro and PCA tumor growth and lymph node/lung metastases in vivo. Synergizes with Taxol .
Alaoui-Jamali et al (2009) A novel experimental heme oxygenase-1-targeted therapy for hormone-refractory prostate cancer. Cancer Res. 69 8017 PMID:19808972
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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