Osocimab |
Catalog No.GC72438 |
Osocimab (BAY 1213790), 항 fxia 항체 (Ki=2.4 nM;EC50 = 0. nM)이다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2056878-75-0
Sample solution is provided at 25 µL, 10mM.
Osocimab (1.4 nM-1 μM; 30 min) inhibits thrombin generation, and also inhibits FXIa-mediated activation of FIX (FIX conversion) (IC50=16 nM) and FXIa mediated substrate cleavage (IC50=1.2 nM) in human plasma[1].
Osocimab (22.05 mg/mL) inhibits intrinsic pathway-mediated activation of the coagulation cascade[1].
References:
[1]. Schaefer M, et al. Allosteric Inhibition as a New Mode of Action for BAY 1213790, a Neutralizing Antibody Targeting the Activated Form of Coagulation Factor XI. J Mol Biol. 2019 Dec 6;431(24):4817-4833.
Average Rating: 5
(Based on Reviews and 30 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *