Panitumumab (anti-EGFR) |
| Catalog No.GC66333 |
Panitumumab(항-EGFR)은 항종양 활성이 있는 완전 인간 IgG2 항-EGFR 단일클론 항체입니다. 821d96072c2d58d8970e76f526b0f6b8Panitumumab(항-EGFR)은 종양 세포 증식, 생존 및 혈관 신생을 억제합니다. 821d96072c2d58d8970e76f526b0f6b8Panitumumab(항-EGFR)은 결장암과 같은 암 연구에 사용될 수 있습니다.821d96072c2d58d8970e76f526b0f6b8
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Panitumumab (anti-EGFR) is a fully human IgG2 anti-EGFR monoclonal antibody with anti-tumor activity. Panitumumab (anti-EGFR) inhibits tumor cell proliferation, survival and angiogenesis. Panitumumab (anti-EGFR) can be used in the research of cancers, such as colon cancer[1][2][4].
Panitumumab (2 nM-2 μM, 3 h) (anti-EGFR) inhibits ligand-dependent autophosphorylation in EGFR-expressing NCI-H1975 cells, NCI-H1650 cells and CHO cells[3].
Panitumumab (0-200 μg/mL, 48 h) (anti-EGFR) inhibits the proliferation of DLD-1 cells[4].
Panitumumab (80 μg/mL, 24 h) (anti-EGFR) increase beclin-1 (a marker of autophagy) levels in Caco-2 cells and DLD-1 cells[4].
Western Blot Analysis[3]
| Cell Line: | EGFR-expressing NCI-H1975 cells, NCI-H1650 cells and CHO cells |
| Concentration: | 2, 20, 200, 2000 nM |
| Incubation Time: | 3 h |
| Result: | Inhibited ligand-induced autophosphorylation of EGFR. |
Panitumumab (25, 100, or 500 μg/mouse, i.p., twice a week) (anti-EGFR) inhibits tumor growth in NCI-H1975 and NCI-H1650 xenografts, compared with control (P < 0.0003)[1].
| Animal Model: | NCI-H1975 and NCI-H1650 xenografts[3] |
| Dosage: | 25, 100, or 500 μg/mouse |
| Administration: | Intraperitoneal injection (i.p.), twice a week |
| Result: | Inhibited ligand-induced EGFR phosphorylation, tumor growth, and markers of proliferation. Decreased Ki-67 and phospho- mitogen-activated protein kinase (pMAPK) staining in both xenografts. |
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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