PCSK9 degrader 1 |
| Catalog No.GC70635 |
PCSK9 degrader 1 (화합물 16) 는 전단백전환효소인 고초균 프로테아제 시료 / kexin 9형 (PCSK9) 의 소분자 배합체로 PCSK9에 높은 친화력을 나타내며 Ki는 107nM이다.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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PCSK9 degrader 1 (Compound 16; 1.25-20 μM; 24 hours; HEK293 cells) treatment shows a clear concentration-dependent degradation of both the pro and mature form of PCSK9 yielding a half-maximal degradation concentration of 4.8 and 3.4 μM, as well as a maximum percentage of degradation at 20 μM of 58% and 61%, respectively[1].
References:
[1]. Petrilli WL, et al. From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9. Cell Chem Biol. 2019 Oct 22. pii: S2451-9456(19)30322-8.
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