PD-L1-IN-1 |
| Catalog No.GC63984 |
PD-L1-IN-1은 IC50이 115nM인 강력한 PD-L1 억제제입니다. PD-L1-IN-1은 PD-L1 단백질과 강력하게 결합하여 PD-L1 발현 암세포(PC9 및 HCC827 세포)와 말초혈액 단핵세포의 공동 배양에서 이 단백질에 도전하여 후자의 항종양 면역 활성을 향상시켰다. PD-L1-IN-1은 건강한 세포에서 낮은 세포독성과 함께 암 세포의 인터페론 γ 방출과 세포자멸사 유도를 유의하게 증가시켰습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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PD-L1-IN-1 is a potent PD-L1 inhibitor with an IC50 of 115 nM. PD-L1-IN-1 strongly binds with the PD-L1 protein and challenged it in a co-culture of PD-L1 expressing cancer cells (PC9 and HCC827 cells) and peripheral blood mononuclear cells enhanced antitumor immune activity of the latter. PD-L1-IN-1 significantly increased interferon γ release and apoptotic induction of cancer cells, with low cytotoxicity in healthy cells[1].
[1]. Russomanno P, et al. Interfering with the Tumor-Immune Interface: Making Way for Triazine-Based Small Molecules as Novel PD-L1 Inhibitors. J Med Chem. 2021;64(21):16020-16045.
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)
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