PDK1-IN-RS2 |
| Catalog No.GC66474 |
PDK1-IN-RS2는 펩티드 도킹 모티프(PIFtide)의 모방체이며 Kd가 9 μM인 기질 선택적 PDK1 억제제입니다. 821d96072c2d58d8970e76f526b0f6b8PDK1-IN-RS2는 PDK1에 의한 다운스트림 키나아제 S6K1의 활성화를 억제합니다.821d96072c2d58d8970e76f526b0f6b8
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Cas No.: 1643958-89-7
Sample solution is provided at 25 µL, 10mM.
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PDK1-IN-RS2 is a mimic of peptide docking motif (PIFtide) and is a substrate-selective PDK1 inhibitor with a Kd of 9 μM. PDK1-IN-RS2 suppresses the activation of the downstream kinases S6K1 by PDK1[1].
PDK1-IN-RS2 stimulates the catalytic activity of PDK1 toward a peptide substrate by sixfold. The sulfonyl group of PDK1-IN-RS2 interacts with Arg131 through a salt bridge, because the sulfonamide is likely ionized under the crystallization conditions[1].
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